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cron4healthyfuture
Joined: 22 Jun 2006
Posts: 13
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 Posted: Fri Jun 23, 2006 4:45 pm Post subject: Caffeine with exercise yields more extracellular Hsp72 |
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Hsp72 is a "heat-shock" protein, a "chaperone" that helps shepard wayward proteins in the cell. This general class of proteins is thought to be "anti-aging", as many protein biologists would consider cellular physiology to be merely an epiphenomenon of the manifestation of the appropriate tertiary and quaternary structures of the constituent proteins of the cell. In other words, you "are" your enzymes and transcription factors, and Heat-shock proteins keep those proteins "on-line". Additionally, it is increasingly appreciated that they can exert direct effects (independent of actually restoring tertiary structure) that are generally regarded as "pro-survival".
However, this study fixated on extracellular Hsp72, which is a little "non-canonical" in regards to the general classification of heat-shock proteins. It is thought to play more of a role in immunological regulation than trying to guard against protein misfolding. In fact, it is thought to actually induce the release of proinflammatory cytokines.
In any case, I thought it was interesting that caffeine during exercise seemed to increased Hsp72 more so than without. The researchers associated that elevation with caffeine. This could cut two ways, in that Hsp72 elevations may be an indication that something is going "wrong", but, on the other hand, it may be an indication that protection is augmented. It is something that needs to be followed up on, that much is for sure.
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| "Caffeine supplementation and exercise was associated with a greater eHsp72 response than exercise alone (Post exercise CAFF 8.6± 1.3 ng/ml; PLA 5.9± 0.9 ng/ml). This greater eHsp72 response was associated with a greater epinephrine response to exercise in CAFF. There was a significant increase in norepinephrine and cortisol, with no intertrial differences. The present data suggests that, in humans, catecholamines may be an important mediator of the exercise-induced increase in eHsp72 concentration." - J Appl Physiol June 22, 2006 |
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